SMART Personalized Chemotherapy

Despite progress in the treatment of tumors, resistance to chemotherapy drugs and inter-individual differences in sensitivity to drug treatment remain a substantial obstacle to the healing of many patients. TICheP project aims to develop an innovative technological framework for the development of a personalized chemotherapy allowing reduced toxicity treatment. It will use ovarian carcinoma as a model, but it has the potential for extension to other types of tumors.

Project co-funded by the Regional Operational Program (POR) FESR 2014-2020 “Investimenti a favore della crescita e dell’occupazione” – Activity 1.3.b – DGR No. 1489/2017. Total eligible project expenditure: €1,185,420.00 – Total funded project contribution: €862,037.00. Operation start date 05/11/2018. Operation end date 05/02/2022 (updated figure).

Technology

The project proposes the development of a perfusion microfluidic  totally automated system for the execution of pharmacological sensitivity tests and imaging to be performed on peritoneal carcinosis cells taken from a patient. The automated tests evaluate the individual response to chemotherapeutic drugs.

News

New paper funded thanks also to Tichep project

The paper “A new role for IDH1 in the control of ovarian cancer cells metabolism and senescence” and “TIMP-1 Is Overexpressed and Secreted by Platinum Resistant Epithelial Ovarian Cancer Cells” were published. Both were partly funded by Tichep project showing the advances in research by this collaborative research effort. Citing info and links to the …

Personalized medicine was presented to Senate President Maria Elisabetta Alberti Casellati

IRS presented Tichep project to Senate President Maria Elisabetta Alberti Casellati at the Polo Tecnologico Alto Adriatico.The TICheP project developed an innovative technological framework for the development of personalized chemotherapy to enable treatment with reduced toxicity. The study used ovarian carcinoma as a model, but has the potential for extension to other tumor types. Some …

Event: innovative technological framework for the development of personalized chemotherapy

EVENT WILL BE HELD APRIL 28, 2022, H 10:00-11:30 a.m. AT THE HIGH ADRIATIC TECHNOLOGY POLE-BLUE ROOM AND ON THE ZOOM PLATFORM Despite advances in cancer treatment, chemotherapy drug resistance and interindividual differences in sensitivity to drug treatment remain a substantial obstacle to cure for many patients. The TICheP project developed an innovative technological framework …